Cell and Developmental Biology

Our research explores how development is shaped by genetic, cellular and environmental factors. We combine genomics, developmental biology, and comparative models to uncover conserved processes and new mechanisms.

We study diverse organisms and processes to uncover the common principles and evolutionary innovations that drive life. Our goal is to understand how life preserves, reshapes, and diversifies its fundamental building blocks across generations. We investigate the cellular and molecular mechanisms that shape development and evolution, focusing on key processes: the inheritance of mitochondria and germline formation, the role of microglia in embryonic neurogenesis, the impact of environmental pollution on embryogenesis, and how neuronal diversity emerges and evolves across the animal kingdom. Through comparative and interdisciplinary approaches that integrate single-cell genomics, developmental biology, and comparative approaches in diverse model organisms we want to reveal how genetic, cellular, and environmental factors interact to control development, and how conserved regulatory programs are modified to generate evolutionary innovations.

People

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Pietro Cacialli

Junior assistant professor (fixed-term)

keywords: developmental biology, neurobiology, zebrafish, microglia
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Fabrizio Ghiselli

Associate Professor

keywords: Genome Evolution, Comparative Genomics, Biodiversity Genomics, Molecular Evolution, Mito-Nuclear Coevolution,
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Liliana Milani

Associate Professor

keywords: Germline Development, Mitochondrial inheritance, Evolution
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Marco Passamonti

Associate Professor

keywords: Molecular Phylogenetics, RNA interference, Bivalvia, Mitochondrial DNA, Doubly Uniparental Inheritance (DUI)
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Enzo Spisni

Associate Professor

keywords: Nutrition, Gut, Food hypersensitivity, Gut inflammation, Antitumoral effect of nutrients