Some organism are able to survive and grow in polluted environments, tolerating high PTEs (Potentially Toxic Elements) concentrations and eventually accumulate them into their tissues and organs. This interaction could be useful for biomonitoring purposes or, in case of plants, for phytoremediation activities such as phyto-stabilization or phyto-extraction. Organism attitude to PTEs uptake depends, other than the plant characteristics, on the nature of the contaminant. Total, pseudo-total and bioavailable soils’ PTEs are compared to that of plant(parts).Bio-accumulation in other organisms (e.g.: birds, mussels) has been evaluated in several environments with different contamination degrees, during inter-disciplinary bio-monitoring activities.